From what I've seen on these forums, with good maintenance the most common major failure is the hybrid battery, usually between 150-250k (age factors into this greatly - if you can put 300k on a Prius in 5 years, the battery will likely last, but a 2004 model with only 120k is still likely to fail).
But your Prius’ battery will only run optimally for so long, and it’s important to know the factors that can affect its lifespan. For starters, the distances you travel can affect your battery. If you frequently commute a long distance, your battery’s lifespan may begin to veer toward the lower end of that 8–10 year range.
As in most things, it depends. If you take good care of the little 12v battery, it can last a long time. My 2004 Prius is at 172,000 miles and still has the original 12v (and traction) battery. Full discharges - a small number of full discharges will destroy most lead acid batteries.
Luckily, hybrid vehicle manufacturers in the United States are legally mandated to provide a warranty on high-voltage hybrid battery packs for at least eight years or up to 100,000 miles. If you buy a used hybrid vehicle, U.S. auto manufacturers like Toyota are also legally obligated to transfer the balance of any hybrid battery warranty. How Long Can a Toyota Prius Hybrid Battery Last? According to Toyota, the battery in a Prius is designed to last for the life of the vehicle. This means that, with proper care and maintenance, the battery should last as long as you own the car. However, this doesn't mean the battery will never need to be replaced. On average, a Toyota Prius
However, ten-year warranty periods of ten years or 150,000 miles of service are now the norm on some Japanese-made hybrids, one example being late-model Toyota Prius vehicles. Moreover, manufacturers in the U.S. domestic market are legally obliged to transfer and honor the balance of hybrid battery warranties. This requirement means that if you
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how long do prius batteries last